Once in a while, we as researchers must try something new and has the potential to revolutionize the treatment landscape. Once in a while, we as researchers must try something new and has the potential to revolutionize the treatment landscape. The 1100 trial selects patients who have failed radiation and are not likely to be cured.Preclinical and clinical data suggest that NBTXR3 has the potential to turn CPI non-responders into responders, and that these nanoparticles help induce immunogenesis, turning “cold” tumors into “hot” ones, allowing the immune system to recognize the tumor and get equipped against it. Dr. Tanguy Seiwert maps out Nanobiotix’s Phase I/II 1100 trial studying the potential immunogenic effect of NBTXR3 in head & neck cancer and non-small cell lung cancer patients.